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In vitro and in vivo data suggest that the compound may interact with nitric oxide signaling

Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs

All analytes were normalized on both internal standard ( 13 C 15 ,N-GSH-d5-NEM) as well as protein content of the corresponding sample
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