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The capacity for GSH synthesis is insufficient to maintain GSH concentrations when tissues are exposed to certain drugs or their metabolites (e.g., acetaminophen), redox cycling compounds (e.g., menadione), peroxides (e.g., tertbutyl hydroperoxide), X-rays, or ultraviolet radiation

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41 However, this approach is not without drawbacks: ethanol might present challenges with lipid solubility, efficient removal from liposomes, agitation-related liposome heterogeneity, and low encapsulation efficiency (EE) for hydrophilic compounds

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