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Studies show that probiotics can inhibit the recovery of beneficial genera like Bifidobacterium and Eubacterium after dysbiosis, delaying the restoration of a healthy microbiome (200)

Alterations in the energy matrix of the heart enable increased FA uptake by cardiomyocytes to exceed the oxidative capacity of mitochondria, leading to excessive lipid storage and production of lipotoxic metabolites that impede cardiomyocyte metabolism and contractility, thereby promoting cardiomyocyte death (47)

However, certain subpopulations exhibit distinct patterns

Their study revealed a significant dysregulation of core fucosylation glycopeptides in preoperative versus postoperative serum samples from patients with PDAC