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Accordingly, the present expert panel suggests that DPN should be considered in a patient with prediabetes or diabetes who presents with neuropathic symptoms (involve both sides symmetrically) and/or signs of neuropathy in the presence of DPN risk factors (i.e., advancing age, obesity, hypertension, dyslipidemia, poor glycemic control), with careful consideration of laboratory testing to rule out other causes of distal symmetric peripheral neuropathy and referral for a detailed neurological work-up for a confirmative test of either small or large nerve fiber dysfunction only in atypical cases

It is also the only incretin mimetic approved in both oral and injectable formulations [25, 26]

10.1371/journal.pone.0073065 62 IkedaR.NishimuraM.SunY.WadaM.NakashimaK

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Sodium Ascorbyl Phosphate (Vitamin C)