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Standardizing preclinical models, dosing strategies, biomarkers, and follow-up durations will be essential for improving reproducibility and supporting meta-analytic interpretation

3.8 Folate regulates immune response in hepatic lipid metabolism In addition to hepatocytes, hepatic sinusoidal endothelial cells and HSCs are present in liver tissues and are important cell types involved in the transformation of the hepatic inflammatory response to hepatic fibrosis

By inhibiting P-gp, these agents enhance cellular drug retention but may inadvertently increase systemic drug concentrations, posing toxicity risks for narrow-therapeutic-index medications (e.g., chemotherapeutics, cardiovascular drugs) (32, 8890)

Fenton-like reactions involving other transition metals (such as Cu 2+ , Co 2+ , and Mn 2+ ) can also catalyse similar reactions, including the production of OH - and OH, thus promoting lipid peroxidation [37]