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Les effets gastro-intestinaux les plus courants comprennent : des nauses passagres des douleurs abdominales ou des crampes des pisodes de diarrhe Ces effets sont souvent lis une intolrance aux agents de charge ou aux dulcorants prsents dans certains comprims croquer ou sublinguaux, comme le sorbitol ou le xylitol, plutt qu' la vitamine B12 elle-mme