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Thiopurines in the Treatment of Steroid-Refractory Ulcerative Colitis In the case of steroid resistance, i.e., a lack of clinical improvement during induction therapy, or steroid dependencea clinical remission during steroid therapy, but a flare during dose reduction or within 3 months of discontinuing treatmentnext-line medications are used

10.1007/7854_2019_107 [DOI] [PMC free article] [PubMed] [Google Scholar] Soares MP, Seldon MP, Gregoire IP et al (2004) Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation

There were no Glx differences in basal ganglia (but did not analyze Glu)

3) downstream effectors of mTOR signaling pathway