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Description
All lines of evidence indicate that fast and slow TGR inhibitors bind different conformational states present in the TGR enzymatic cycle induced by both NADPH-dependent reduction and the concomitant destabilization of the polypeptide chain, as shown by TSA
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M., Marchan, R
doi: 10.1007/s00394-006-0593-z
Formation of protein adducts in hepatocytes impairs protein secretion, which has been proposed to play a role in enlargement of the liver (i.e., hepatomegaly)
