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Ethanol metabolism by CYP2E1 generates excess reactive oxygen species (ROS) and depletes glutathione (GSH) in hepatocytes

Mitochondrial impairment and dysregulation of mitochondrial proteins are present in postmortem brain and spinal cord tissues of ALS patients and SOD1 G93A mice (Carr et al., 2003

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Furthermore, ferroptosis exhibits complex cross-regulation with other cell death pathways (e.g., pyroptosis, apoptosis, autophagy), collectively forming a self-amplifying vicious cycle that persistently drives chronic inflammation and tissue destruction

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