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CYP2D6 Metabolism and Pharmacogenomic Variability The liver converts hydrocodone to hydromorphone via CYP2D6 O-demethylation, producing an active metabolite with approximately 30 times higher mu-opioid receptor affinity than the parent compound

[DOI] [PubMed] [Google Scholar] 23.Sun X., Shen J., Wang L

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SakamotoKSuzukiTTakahashiKKoguchiTHirayamaTMoriAet alIron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina

Size, source and chemical composition as determinants of toxicity attributable to ambient particulate matter
