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Atherosclerotic lesions contain a higher concentration of oxidizable phospholipids and oxidized lipoproteins, have pro-inflammatory and low oxygen conditions (microdomains) which reduce antioxidant availability, and in many of these high-risk plaques there is increased redox active iron accumulation via abnormal iron regulation or heme turnover from bleeding

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The Serine protease KLK7 promotes immune cell infiltration in visceral adipose tissue in obesity

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