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Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and uterine natural killer cells significantly mediate these vascular changes [22,23]

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The critical limitation for both compounds is the same: evidence is preclinical, human clinical data is either minimal (BPC-157) or nonexistent (KPV), and both are sourced through unregulated markets where product quality cannot be guaranteed