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This is an advanced technique and should only be undertaken if the experimental design explicitly calls for it

The consequences can range from minor to research-ending

Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus

10.1111/ejn.12872 Eur

Vitamin B-12 status differs among pregnant, lactating, and control women with equivalent nutrient intakes. The Journal of Nutrition 145.7 (2015): 1507-1514
