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This cytokine signaling is a key component of the sickness response ( The core problem with looking for cytokines in peripheral blood is that cytokines generally do not function as endocrine signalers, but are rather normally autocrine and paracrine signalers (see Box 1)

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Consistently, the livers of HFD-fed mice showed increased IKK--SSG levels, decreased IKK- phosphorylation, and suppressed NF-B activation when compared to these from control animals

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Copp, J