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Description
In addition, activation of mTOR can inhibit autophagy induction through the phosphorylation of the autophagic related gene ( Atg ) protein Atg13 and UNC-51 like kinases (ULKs) such as UNC-51 like kinase 1 (ULK1) to prevent formation of the ULK-Atg13-FIP200 complex (97, 458)
Whitehead RD, Re D, Xiao D, Ozakinci G, Perrett DI
Concurrently, NAD + depletion, exacerbated by poly(ADP-ribose) polymerase-1 (PARP-1) hyperactivation, cripples sirtuin activity, impairing mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1) dysregulation and reducing antioxidant defense through Forkhead box O (FOXO) signaling
[DOI] [PubMed] [Google Scholar] 269.Pacheco M.T., Vezza T., Diez-Echave P., Utrilla P., Villamiel M., Moreno F.J
QNT Immunity 90caps - QNT 15.00 (29.34 .) 23.00 (44.98 .) :Immunity ,
