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Moreover, it was pointed out that gliflozin-induced infection, cancers, liver injury, hypoglycemia, and hypovolemia dehydration, hypovolemia, but mostly hypotension or orthostatic hypotension, and hemoconcentration (and thereby, the risk for thrombosis) affected bone metabolism and increased the risk of fracture [42,43,44]

Following further optimization in the PC activation process, for 1 M (62.5 g/ml) PC, the optimal thrombin concentration was 85 nM or 3.12 g/ml (8.5% molar ratio or 5% w/w ratio to PC), whereas higher thrombin concentrations did not result in higher APC generation (see Supplementary Fig

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(2012) NRF2 and cancer: the good, the bad and the importance of context, Nat

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