glutathione and metabolism - an overview Systematic manipulation of glutathione metabolism

J Internal Med

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Important chemical contaminants reported to cause neurotoxic effects in humans at environmentally relevant levels of exposure include polychlorinated biphenyls (Schantz et al., 2003), arsenic (Wasserman et al., 2004), lead (Lanphear et al., 2005), manganese (Takser et al., 2003), pesticides (Rauh et al., 2006), polycyclic aromatic hydrocarbons (Perera et al., 2006) and mercury compounds (Grandjean et al., 1997

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This initiative has enabled the longitudinal tracking of biomarker trajectories and the development of composite endpoints that are gaining acceptance among regulatory agencies for clinical trial evaluation [608]