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Notably, the expression of SLC3A2 and SLC7A11 were also significantly diminished in the treatment group (Figure 7I)

NicholsESteinmetzJDVollsetSEFukutakiKChalekJAbd-AllahFet al

2023 Jan

Given certain caveats, the information obtained through single-cell research has introduced the possibility of improving CAR-T therapies against cancers by manipulating the expression of key metabolism-related genes, proteins or metabolites, leading to CAR-T cell products better suited for immunotherapy

Neuro Oncol 15: 618625 Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS, Rabinowitz JD, Dang CV, Riggins GJ (2010) Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1