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These include calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2, also known as CaMKK) (28), a TRPV1/Ca 2+ /CaMKK2 axis in skeletal muscle cells (29), and a TRPV1/liver kinase B1 (LKB1) pathway in prostate cancer cells (30)

124,127,128 In addition, IDH1 is hyperacetylated in CRC cells and is significantly correlated with distant metastasis and poor survival

We demonstrated therapeutic protection of photoreceptor structure and function in a chemically-induced rat model of RP (48% increase in photopic b-wave amplitude), as well as some limited protection in an aggressive genetic mouse model ( rd10 ) of retinal degeneration (~ 31% increase in photopic b-wave amplitude) with once daily application