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For example, the compound isoegomaketone isolated from the plant P

Long-Term Durability : Many patients maintain positive outcomes for 5-10 years OCA is a highly effective treatment for large, complex cartilage defects with bone involvement, offering durable pain relief and functional recovery

Whilst peptidic inhibitors have been developed to weaken the integrity of the shelterin complex or target its interactions with partners, the direct modulation of protein interactions within shelterin using small molecules has been largely unexplored 12,13