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The -butyrobetaine dioxygenase enzyme, as well as the first enzyme of carnitine synthesis (trimethyllysine hydroxylase, encoded by the TMLHE gene), are members of the large family of 2-oxoglutarate and ferrous (Fe 2+ ) iron-dependent dioxygenases
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As random changes tend to fluctuate, a steady progressive increase is unlikely to be due to chance
Front Physiol 5 , 164, (2014)
