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This approach is best suited to: Adults 4065 with longevity-focused health goals who are already engaged in foundational health optimisation (sleep, nutrition, resistance training, metabolic health) Individuals with confirmed age-related decline in GH/IGF-1, with symptoms including reduced lean mass, increased visceral fat, impaired recovery, or sleep-quality deterioration Patients with chronically elevated inflammatory markers without acute disease Adults with disrupted circadian rhythm or age-related sleep degradation (Epitalon specifically addresses this) Those who have optimised foundational lifestyle variables and want an additional, evidence-informed intervention layer It is not appropriate as a standalone intervention for adults who have not addressed metabolic health, sleep, or body composition fundamentals

70 Moreover, in SURPASS-4, WL and improvement in HbA1c was maintained for 2 years with tirzepatide, providing some initial evidence for sustained improvements over time