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Mechanistically, sulforaphane, by virtue of forming dithiocarbamate through a reaction with thiol groups, can directly interact with DNA binding and the transactivation of NF-B [325]

The success of compounds such as APR-246, CP-31398, and MIRA-1 as well as gene therapies and immunotherapies in preclinical and early clinical settings for blood cancers, along with ongoing clinical trials (Table 6), is a testament to their promise in treating hematologic malignancies

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Metallomics study using hair mineral analysis and multiple logistic regression analysis: relationship between cancer and minerals