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If your gut has an issue with recycling B12, you will just consume all the B12 in your injection

B12 Benefits If you are deficient, B12 injections may improve mood, strengthen your skeleton, boost energy levels, and improve memory

by Dr Hayley Willacy, FRCGP Further reading and references Aphthous ulcers

A 25 to 27 gauge needle is appropriate, as it minimizes discomfort and is sufficient for penetrating the subcutaneous layer without reaching the muscle