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Primer pairs oriTF/oriTR, gr IF/ gr IR, and gr OF/ gr OR were used to confirm the deletion of gr

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Platinum(IV) complexes with non-cisplatin-like mechanisms of action Before it became established that most anticancer-active platinum(IV) complexes function as prodrugs that undergo reduction to release active platinum(II) agents, alternative mechanisms of action for platinum(IV) were envisioned

10.1038/s41598-018-27179-6 12 KietzmannT

This NFE2L2 genetic baseline is the transcriptional layer above all the individual enzyme variants described above: it sets the stress-responsive amplification capacity of the entire glutathione synthesis, recycling, and deployment network