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Even though noradrenergic dysfunction is linked to PD non-motor symptoms, a preclinical study indicates that the loss of LC norepinephrine, and, consequently, its immune-modulatory and neuroprotective activities, may exacerbate or even accelerate the progression of PD [400]

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However, many diet plans sold by companies today lack evidence-based efficacy and may be inadequate for addressing long-term chronic weight management issues associated with obesity

7: Masnec S, Kokot A, Kralj T, Zlatar M, Loncaric K, Sablic M, Kalauz M, Beslic I, Oroz K, Mrvelj B, Beketic Oreskovic L, Oreskovic I, Strbe S, Staresinic B, Slivsek G, Boban Blagaic A, Seiwerth S, Skrtic A, Sikiric P

however, increasing responses are seen at doses of 0.4 mg and 0.6 mg