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Five decades with polyunsaturated fatty acids: chemical synthesis, enzymatic formation, lipid peroxidation and its biological effects

Moreover, metformin improves mitochondrial function and contributes to helping restore hormonal balance and insulin sensitivity in PCOS patients (Rabah et al., 2023)

However, their implementation in clinical practice should be approached with caution: the current evidence is encouraging, but it still has some important limitations, like small sample sizes, heterogeneity in dosing and treatment duration, and a lack of standardization in its formulations

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After stroke, microglial activation results in the release of several inflammatory mediators, many of which have cytotoxic or cytoprotective properties