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Zhu et al49 revealed that the DA D3 receptor regulates basal pain sensitivity in mice, aligning with Gardners group, which highlighted the importance of the D3 receptor in heroin and oxycodone reinforcement

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Conversely, ACSL4 expression, along with levels of ROS, MDA, 4-HNE, Fe 2+ , and -synuclein, were markedly elevated, thereby exacerbating ferroptosis and lipid peroxidation in the brain

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567 A comprehensive evaluation of octadecanoids as effectors of the TRP-superfamily would appear to be extremely valuable and may unravel potential mechanisms of action in various cell systems