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Phase 3 protocols often begin at 2mg
Geology also plays an important role in governing groundwater responses to climate variability
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The meta-analysis found that SGLT2 inhibitors were associated with a 10% reduced risk of major adverse cardiovascular events, a 22% reduced risk of heart failure or cardiovascular death, and a 38% risk reduction in a composite of adverse kidney outcomes (Inzucchi 2021)
