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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]
Clinical studies have established that 250mg of magnesium oxide taken daily represents an effective dose for RLS symptom reduction, based on the landmark trial that demonstrated significant improvements after two months of supplementation
doi: 10.1038/mp.2015.96
