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In epithelial cells, expulsion is via the external or luminal face The Need for Drug Metabolism Many cells that act as portals for entry of external molecules into the body (eg, pulmonary epithelium, intestinal epithelium) contain transporter molecules (MDR [P-glycoprotein] family, MRP family, others) that expel unwanted molecules immediately after absorption

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The leap from animal model findings to confirmed human benefit is significant, and many compounds that show promise in preclinical research do not translate successfully to human medicine