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The association between smoking and low back pain: a meta-analysis

Finally, a pervasive sense of being overwhelmed by the cumulative burden of these multisystem symptoms can serve as a valuable clinical indicator for nociplastic pain [12, 75]

Metformin suppresses foam cell formation, inflammation and ferroptosis via the AMPK/ERK signaling pathway in oxLDLinduced THP1 monocytes

Aging remains the most prominent risk factor, amplifying neuronal susceptibility due to diminished proteostasis, mitochondrial function, and bloodbrain barrier integrity [28]

The net result of these actions is inhibition of C-fibre-evoked postsynaptic excitation, although TRPA1-mediated calcium influx may initially increase spontaneous excitatory postsynaptic currents via activation of ionotropic glutamate receptors (iGluR)