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doi: 10.1038/s41598-020-73741-6 119

Subsequent research must further clarify the role of the MGBA axis across varying malignancies, radiation site, and dose parameters (Li et al., 2022)

GH and IGF System Growth hormone (GH) and the insulin-like growth factor (IGF) system consists of several components: GH, and receptor (GHR), IGF1, IGF2, Insulin-like growth factor 1 receptor (IGF1R), Insulin Like Growth Factor 2 Receptor (IGF2R), IGF binding proteins (IGFBPs), and related proteases which interact with each other and regulate several metabolic processes and body growth ( GH, also known as somatotropin, is produced in the anterior pituitary under the control of growth hormone releasing hormone (GHRH) which induces its synthesis and release ( The bioavailability of both IGF1 and IGF2 is controlled by a superfamily of six IGFBPs (IGFBP 1-6) characterized by a higher affinity for IGFs than IGF receptors ( The GH and IGF system have growth-promoting actions regulating cell proliferation, differentiation, apoptosis and angiogenesis ( MicroRNAs and Long Non-Coding RNAs Are Epigenetic Regulators of Gene Expression MicroRNAs (miRNAs) are a family of small non-coding RNAs (1925 nucleotides -nts) that can regulate a plethora of biological processes via the modulation of the expression of target genes at the post- transcriptional level ( MiRNAs act in a very specific, context-dependent manner, and may have a dual role both as onco-miR and tumor-suppressor miR ( Long non-coding RNAs (lncRNAs) are non-protein coding transcripts with a minimal length of 200 nts, that are important emerging gene expression regulators