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doi:10.1001/jamacardio.2019.3780 Glavinovic T, Thanassoulis G, de Graaf J, Couture P, Hegele RA, Sniderman AD

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If left untreated, Peyronies disease can lead to several significant complications: Physical Changes, Progressive Deterioration About 80-90% of untreated cases either remain unchanged or worsen over time, with only 10-12% showing spontaneous improvement