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Redox homeostasis underlies all important cellular activities and ALS is a systemic disease that affects multiple cellular processes

Substrate availability Mitochondria burn both carbohydrates and fats for fuel

GSH turnover may be considered as a multi-organ process

IHC synapses can immediately and permanently degenerate after noise exposure, independent of hair cell loss, whereas the cell bodies and central projections of cochlear neurons can survive for months to years, providing an extended therapeutic window for improving afferent input through synapse regeneration

one such mechanism includes increased intestinal permeability or the leaky gut, which is very prevalent in the case of PD