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Description
Biomedical Dermatology
If it goes the estrogen route, androstenedione is converted (using CYP19A1) first to estrone (E1), which is then converted (using 17-HSD) into estradiol.[ref] Here is a flow chart to give you a better idea of the conversion of cholesterol into estrogen, including the genes that are involved
However, it is essential to proceed with caution
Mild pigmentation concerns 5
Interestingly, most inhibitors of TrxR1, or conditional knockout of the enzyme in mouse tissues, typically leads to strong upregulation of Nrf2 also without evident signs of oxidative stress
