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Because GTK is (1) particularly prominent in vitro as a -lyase with toxic cysteine S -conjugates such as TFEC (Table 1), (2) the enzyme is present in rat and human kidney proximal tubules (e.g., Jones et al., 1988, Cooper et al., 1993, Kim et al., 1997), and (3) the proximal tubules are especially prone to damage from toxic halogenated cysteine S -conjugates

* The biological effect of a tumorigenic mutation in Kelch-like ECH-associated protein 1 ( KEAP1 ) or NFE2-related factor 2 ( NRF2 ) is typically the activation of NRF2 target genes

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doi: 10.1074/jbc.271.11.6000