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In melanocytes, depending on the type of kinase and cell line, so far it has been proven that kinases play a dual role in Nrf2 activity regulation, e.g., increased activity of JNK (c-Jun N-terminal kinase) enhances Nrf2 expression in melanocytes line PIG1 but reducing its activation PIG3V cells 69

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Logically, local administration of antioxidant agents into the target site may be comparably superior, especially considering the increase in bioavailability and accurate targeting of the joint, bypassing the pharmacokinetic challenges and reducing exposure to inappropriate sites

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