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With increase in glycolysis, the tumor microenvironment becomes acidic

J Clin Pharm Ther Med 21:537542 Ye Q, Huang B, Zhang X, Zhu Y, Chen X (2012) Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis

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In contrast, Cannabis offers no relief against nociceptive pain or hyperalgesia as demonstrated by its inability to reduce pain induced by electrical stimulation, heat, capsaicin, or secondary sunburn induced hyperalgesia in a well-designed placebo-controlled crossover study in 18 subjects [91]

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