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Abbreviations ADI-R: Autism diagnostic interview - revised ALAD: Delta aminolevulinic acid dehydratase CARS: Childhood Autism Rating Scale CNS: Central nervous system d.f.: Degrees freedom DSM: American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders fGSH: Free reduced glutathione GCL: Glutamate cysteine ligase GCT: -glutamyl cyclotransferase GGT: -glutamyl-transferase GPx: Glutathione peroxidase GSH: Reduced glutathione GSH: GSSG: Glutathione redox ratio GSH-R: Glutathione reductase GS: Glutathione synthetase GSSG: Oxidised glutathione GST: Glutathione-S-transferases Mg 2+ : Magnesium ions Mn 2+ : Manganese ions Q: Cochran's Q (a measure of statistical heterogeneity) SMD: Standardised mean difference tGSH: Total glutathione References Wing L, Gould J: Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification

A recent study by Jeon and colleagues showed that senescent chondrocytes accumulate around traumatic cartilage lesions and are associated with the development of arthritis

Our aim is not to produce a list of defective pathways but to identify common patterns/pathways which may underpin a common etiology in these three conditions