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Among these 13 patients, SALT 50 and SALT 100 was observed in 6 (46.2%) and 2 (9%) patients, respectively

Rujner J, Socha J, Wojtasik A, et al

Mast cells, a potent contributor to the release of inflammatory mediators, including histamine, are identified in increased quantity in rosacea patients, and receptors for histamine and serotonin, leading to vasodilatory effects, are upregulated in all forms of rosacea

Further research has demonstrated that RA signaling is enriched in depression-related brain regions (30)