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It is interesting to note that glutaredoxins (Grx12) also utilize GSH to reduce protein intra/inter-disulfides (PS 2 or protein-glutathione disulfide [PSSG]) into protein sulfhydryl groups (-SH) (7, 8) (Fig

[DOI] [PubMed] [Google Scholar] 60.Johnson J.L., Rajagopalan K.V

In that study, lncRNAs (different between ovarian tumor tissues and normal tissues) were associated with ferroptosis genes

* L-Cysteine is typically consumed in lesser amounts in the diet compared to other amino acids needed for glutathione synthesis, such as glutamate and glycine

The gut microbiome may also influence the expression of genes associated with metabolism 2,5