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In a study by Zhao et al., the primary follicles were triggered by IGF-1 through the measurement of DNA increase in follicular cells

While passive diffusion was initially proposed as the main absorption route, recent evidence indicates that specific transmembrane transporters including Na-taurocholate cotransporting polypeptide, organic anion-transporting polypeptides, L-type amino acid transporters, and monocarboxylate transporters also facilitate LT4 uptake

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Nanotechnology is being utilized to create braintargeted delivery systems for curcumin, resveratrol, quercetin, and other compounds to navigate the pharmacokinetic barriers that diminish the efficacy of these substances in vivo [76, 109]

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