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While osteoporosis is primarily considered a skeletal disorder, there is growing recognition of the intricate interactions between bone metabolism and systemic metabolism in addition to ageing, hormonal changes, nutrient deficiency and the inflammatory processes that arise as a consequence of obesity, diabetes, insulin resistance, and metabolic syndrome

Its the first principle of secretagogue research and these three compounds exist in the literature precisely because no single one answers all of the questions

2013;13(2), e9308

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Increases systemic lipolysis by acting directly on adipocyte walls