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Regulation of this response is facilitated by the antioxidant responsive element (ARE) which is located in the promoters of many of the genes that are induced by oxidative and chemical stress [47]

Progressing to the critical juncture of intestinal barrier dysfunction amelioration, this therapeutic triumvirate of curcumin, hirudin, and Panax notoginseng saponins functions as molecular guardians, meticulously preserving the structural sanctity of tight junction protein complexes and epithelial architectural integrity, thereby establishing formidable barriers against the pathological permeability escalation that epitomizes CKD pathogenesis

Consequently, it aids in the enhancement of memory [119]

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