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Another recently discovered mechanism of action is that LDN reduces inflammation in the central nervous system

[DOI] [PubMed] [Google Scholar] Clark D, Durner J, Navarre DA, Klessig DF

doi: 10.1177/11795476241242265

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Due to the shortened C-terminus, the archaeal enzyme structures lack hydrogen bonds, which are formed between amino acids (Lys426 and Tyr430) of one subunit with the 2- and 3-hydroxy groups of the adenosine moiety and the pyrophosphate of NAD + bound in the adjacent subunit, present in Mm SAHH and other mesophilic homologues