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However, patients did not receive folate supplementation in that particular study

D51.9 Vitamin B12 Deficiency Anemia, Unspecified Use when low B12 is confirmed as the cause of anemia, but the specific mechanism is not documented in the record

The label positions 2.5 mg as the starter before 5 mg, but short non-diabetic data show weight and insulin-resistance movement at 2.5 mg. That makes it a defensible low-dose floor for selected users

PMID 12410623

Effects on cellular NAD+ and SAM pools in vitro
