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226 Moreover, HIF activation promotes cell proliferation and inhibits apoptosis in renal IR-induced AKI, and these effects can be reversed by treatment with the -catenin inhibitor IWR-1-endo, indicating interaction between HIF and the Wnt/-catenin signaling pathway in providing renal protection

DFO is not orally active and needs to be administered intravenously or subcutaneously (Merlot et al., 2013)

These enzymes are vital for protecting thyroid cells from oxidative stress, a byproduct of thyroid hormone synthesis

3 Results 3.1 Impact of LPS and/or OXY on relative testicular weight, testosterone level, oxidative stress markers The data presented in Figure 1 indicated a reduction in the relative testicular weight in the LPS-exposed group compared to controls which was nonsignificant, however, testosterone level in the LPS group recorded a remarkable decrease relative to the control rats

It facilitates the expulsion of milk during breastfeeding and the contraction of the uterus during childbirth (Uvns-Moberg et al., 2019)