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Other established risk factors include: Hyperlipidemia Metabolic syndrome Obesity Atrial fibrillation Chronic kidney disease Sedentary lifestyle Sleep disorders, particularly obstructive sleep apnea Sleep disorders may contribute to CSVD through intermittent hypoxia, sympathetic activation, endothelial dysfunction, and impaired glymphatic clearance

If elevated ROS and/or lower antioxidant activities are responsible for the damage done to gametes and embryos incubated in PF and FF of endometriosis patients, then the addition of antioxidants to PF and FF incubation medium should decrease rates of gamete and embryo damage