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For CD8 + T cells, antigen peptide recognition on MHC class I molecules by professional APCs (such as DCs) provides signal one, while CD80/CD86-CD28 interactions provide the critical co-stimulatory signal two (107)

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Endolysosomal zinc dysregulation Defects in the endosomeautophagosomelysosome pathway, the major machinery for degrading protein aggregates and damaged organelles, are central drivers of neurodegenerative diseases such as Alzheimers disease, Parkinsons disease and ALS 166